Publications by authors named "A M O'Keeffe"
Background: Deep brain stimulation is a treatment for advanced Parkinson's disease and currently tuned to target motor symptoms during daytime. Parkinson's disease is associated with multiple nocturnal symptoms such as akinesia, insomnia, and sleep fragmentation, which may require adjustments of stimulation during sleep for best treatment outcome.
Objectives: There is a need for a robust biomarker to guide stimulation titration across sleep stages.
Modeling immune cell recruitment by liver endothelial cells in vitro is important to better understand the pathology of chronic inflammatory liver diseases and cancers. Here, we present a protocol for the study of monocyte transmigration across activated primary human liver endothelial cells, under physiological flow conditions. We describe primary endothelial cell isolation from human liver tissues and monocyte isolation from human blood.
View Article and Find Full Text PDFBackground: Patient experience is routinely collected in the clinical environment in many different ways throughout various person-provider encounters, but so far limited research focused on understanding the methods of using it to improve the quality of healthcare. This paper presents a protocol for a methodological scoping review examining the methods of obtaining, analysing, reporting, and using patient experience data for quality improvement in rehabilitation settings.
Methods: The scoping review will be conducted according to the guidelines from the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis and the methodological framework by Arksey & O'Malley.
Article Synopsis
- Severe COVID-19 patients frequently experience coinfections with bacterial and fungal pathogens, leading to higher mortality rates compared to infections with just one pathogen.
- A study investigated blood and respiratory samples from hospitalized patients to analyze the relationship between SARS-CoV-2 and coinfections, finding no specific lineage associated with COVID-19 but noting trends in the virulence of bloodstream strains.
- Research using a mouse model demonstrated that SARS-CoV-2 infection increases susceptibility to subsequent infections with low-cytotoxicity pathogens, highlighting the enhanced risk of severe outcomes from these coinfections.
Objectives: To evaluate the feasibility and acceptability of a primary care-based intervention for improving post-diagnostic dementia care and support (PriDem), and implementation study procedures.
Design: A non-randomised, mixed methods, feasibility study.
Setting: Seven general practices from four primary care networks (PCNs) in the Northeast and Southeast of England.