Optical molecular imaging in oral- and oropharyngeal squamous cell carcinoma using a novel uPAR-targeting near-infrared imaging agent FG001 (ICG-Glu-Glu-AE105): An explorative phase II clinical trial.

: In oral and oropharyngeal squamous cell carcinoma (OSCC, OPSCC), frequent inadequate surgical margins highlight the importance of precise intraoperative identification and delineation of cancerous tissue for improving patient outcomes. : A prospective, open-label, single-center, single dose, exploratory phase II clinical trial (EudraCT 2022-001361-12) to assess the efficacy of the novel uPAR-targeting near-infrared imaging agent, FG001, for intraoperative detection of OSCC and OPSCC. Macroscopic tumor detection was quantified with sensitivity and intraoperative tumor-to-background ratio (TBR).

Comprehensive evaluation of accelerometer-based physical activity in persons with multiple sclerosis - The influence of disability status and its impact on walking capacity.

Introduction: Multiple sclerosis has a substantial negative impact on physical activity (PA). However, limited knowledge exists on objectively measured PA levels and types across disability status along with its influence on walking capacity.

Objectives: To (1) determine PA levels/types in persons with MS (pwMS) (overall and across disability status) and in healthy controls (HC), and (2) investigate the association between PA levels/types and walking capacity.

Work participation after receiving multidisciplinary treatment or acceptance and commitment therapy intervention for return to work: long-term follow-up of a randomized controlled trial among sick-listed individuals with mental disorders and/or chronic pain.

Background: The return-to-work (RTW) process for individuals on long-term sick leave can be complex. Vocational rehabilitation may facilitate RTW; however, many intervention studies often have relatively short follow-up periods. The purpose of this study was to assess long-term work participation 2-7 years after the initiation of a three-armed randomized controlled trial aimed at RTW for individuals on long-term sick leave because of mental disorders and/or chronic pain.

Does lifting female piglets by one hind leg increase the risk of umbilical and hind leg lesions?

Background: Umbilical lesions in pigs have a negative impact on animal welfare and productivity. It has been suggested that lifting young piglets by one hind leg may be a risk factor for developing omphalitis and umbilical hernia. However, the hypothesis that lifting piglets by one hind leg should stretch the umbilical wall and impede the healing of the umbilicus has not yet been investigated.

Synergetic Effects of Soil Organic Matter Components During Interactions with Minerals.

Mineral-associated soil organic matter (SOM) is critical for stabilizing organic carbon and mitigating climate change. However, mineral-SOM interactions at the molecular scale, particularly synergetic adsorption through organic-organic interaction on the mineral surface known as organic multilayering, remain poorly understood. This study investigates the impact of organic multilayering on mineral-SOM interactions, by integrating macroscale experiments and molecular-scale simulations that assess the individual and sequential adsorption of major SOM compounds-lauric acid (lipid), pentaglycine (amino acid), trehalose (carbohydrate), and lignin onto soil minerals.