Publications by authors named "A M Motley"
Carboxyhemoglobin as Potential Biomarker for Cardiac Surgery Associated Acute Kidney Injury.
J Cardiothorac Vasc Anesth
October 2024
Objectives: Carboxyhemoglobin (CO-Hb) is a marker of hemolysis and inflammation, both risk factors for cardiac surgery-associated AKI (CSA-AKI). However, the association between CO-Hb and CSA-AKI remains unknown.
Design: A retrospective cohort study.
Article Synopsis
- Cardiac surgery using cardiopulmonary bypass (CPB) can cause hemolysis, and the study investigates carboxyhemoglobin (CO-Hb) as a potential marker for this condition.
- The research analyzed data from 1,735 patients and found that CO-Hb levels significantly increased post-surgery, peaking 2.1 times higher than baseline levels about 17 hours after the procedure.
- Several factors, such as age, respiratory disease, and amount of red blood cell transfusions, were associated with higher CO-Hb levels, which also correlated with increased bilirubin levels, suggesting CO-Hb's potential as a valuable biomarker for monitoring hemolysis in cardiac surgery patients.
Background: A Functional Medicine program was developed at an inflammatory bowel disease (IBD) center with the goal of integrating strategies to address modifiable lifestyle factors and to complete a 6-week elimination diet under the direction of a trained Functional Medicine dietitian and Functional Medicine providers.
Methods: From January 2019 to November 2019, patients with controlled, but persistent, symptoms from IBD were offered enrollment. Each of the 5 visits incorporated an educational session focused on nutrition followed by a session focusing on modifiable lifestyle factors.
Background & Aims: Patients with inflammatory bowel disease (IBD) demonstrate nutritional selenium deficiencies and are at greater risk of developing colon cancer. Previously, we determined that global reduction of the secreted antioxidant selenium-containing protein, selenoprotein P (SELENOP), substantially increased tumor development in an experimental colitis-associated cancer (CAC) model. We next sought to delineate tissue-specific contributions of SELENOP to intestinal inflammatory carcinogenesis and define clinical context.
View Article and Find Full Text PDFCrohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls.
View Article and Find Full Text PDF