Publications by authors named "A M Moormann"
The WHO recommends hepatitis B birth-dose vaccination (HepB-BD), but it is not routinely given in most sub-Saharan African countries. We aimed to assess the immunogenicity of HepB-BD in addition to the existing hepatitis B vaccine (HepB3) schedule in Kinshasa, Democratic Republic of Congo among HBV-unexposed and HBV-exposed infants. Using an open-label, randomised, controlled design, HBV-unexposed infants were randomised (1:1) to receive the standard HepB3 vaccine series (group U3), or to receive HepB-BD in addition to HepB3 (group U4).
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- COVID-19 had a significant impact on minority communities, highlighting the need for better research engagement with these groups, while existing evaluation methods hinder comprehensive analysis.
- A cross-sectional study in Massachusetts showed that 91.4% of 290 participants had received a COVID-19 vaccine, and 41.7% reported past infections, with findings indicating varying antibody responses and lingering symptoms, particularly among middle-aged Latinas.
- The study emphasized the importance of using saliva samples for serology and introduced standardized methods for better future evaluations, enhancing the understanding of COVID-19 and public health responses in underserved populations.
Background: The Zanzibar archipelago of Tanzania has become a low-transmission area for . Despite being considered an area of pre-elimination for years, achieving elimination has been difficult, likely due to a combination of imported infections from mainland Tanzania and continued local transmission.
Methods: To shed light on these sources of transmission, we applied highly multiplexed genotyping utilizing molecular inversion probes to characterize the genetic relatedness of 282 isolates collected across Zanzibar and in Bagamoyo district on the coastal mainland from 2016 to 2018.
COVID-19 disproportionately affected minorities, while research barriers to engage underserved communities persist. Serological studies reveal infection and vaccination histories within these communities, however lack of consensus on downstream evaluation methods impede meta-analyses and dampen the broader public health impact. To reveal the impact of COVID-19 and vaccine uptake among diverse communities and to develop rigorous serological downstream evaluation methods, we engaged racial and ethnic minorities in Massachusetts in a cross-sectional study (April - July 2022), screened blood and saliva for SARS-CoV-2 and human endemic coronavirus (hCoV) antibodies by bead-based multiplex assay and point-of-care (POC) test and developed across-plate normalization and classification boundary methods for optimal qualitative serological assessments.
View Article and Find Full Text PDFBackground: Circulating T-follicular helper (cT ) cells have the potential to provide an additional correlate of protection against ( as they are essential to promote B cell production of long-lasting antibodies. Assessing the specificity of cT subsets to individual malaria antigens is vital to understanding the variation observed in antibody responses and identifying promising malaria vaccine candidates.
Methods: Using spectral flow cytometry and unbiased clustering analysis we assessed antigen-specific cT cell recall responses to malaria vaccine candidates SEA-1A and GARP within a cross-section of children and adults living in a malaria holoendemic region of western Kenya.