Unilateral biportal endoscopy: review and detailed surgical approach to extraforaminal approach.

Foraminal and extraforaminal lumbar disc herniations are common sources of pain and disability. Classic surgical treatments, such as open approach through Witsel technique, often involve resection of the superior articular process to decompress the foraminal space. Unilateral biportal endoscopy (UBE) has emerged as a minimally invasive alternative, providing enhanced visualization and precision while minimizing soft tissue damage.

HIV-2EU - Supporting Standardized HIV-2 Drug Resistance Interpretation: an Update.

Human immunodeficiency virus type 2 (HIV-2) is an attenuated retroviral infection characterized by specific natural susceptibility to antiretroviral drugs and acquired resistance profiles. Based on the latest knowledge of phenotypic data and clinical follow-up, HIV-2 resistance interpretation rules have been updated and implemented in a freely available resistance analysis tool.

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19.

The most common cause of death due to COVID-19 remains respiratory failure. Yet, our understanding of the precise cellular and molecular changes underlying lung alveolar damage is limited. Here, we integrate single cell transcriptomic data of COVID-19 and donor lung tissue with spatial transcriptomic data stratifying histopathological stages of diffuse alveolar damage.

A Totally Laparoscopic Colectomy is Feasible for Acute Complicated Appendicitis with Necrotic Appendiceal Base in the Emergency Setting.

Acute appendicitis remains one of the most common surgical emergencies worldwide. Complicated acute appendicitis may present as perforated or gangrenous appendicitis with a compromised appendiceal base. This is a challenging scenario for surgeons that may require, in some cases, an ileocolic resection.

Structural and biocompatibility challenges for 3D printed microfluidic devices for IVF.

In Vitro Fertilization (IVF) is a widely used treatment for infertility, but success rates for UK women under 35 stand at approximately 32%. Culture conditions significantly affect in-vitro embryo development and treatment efficacy. Over 40 years, IVF procedures evolved, with microfluidic platforms emerging to enhance culture conditions.