Publications by authors named "A M Mercurio"
Introduction: Among older adults with cancer receiving chemotherapy, frailty indices predict OS and toxicity. Given the increased use of immunotherapy and targeted therapy for advanced non-small cell lung cancer (aNSCLC), we evaluated frailty and Karnofsky Performance Status (KPS) among older adults with aNSCLC receiving chemotherapy, immunotherapy, and/or targeted therapy.
Methods: Patients aged ≥ 65 with aNSCLC starting systemic therapy with non-curative intent underwent geriatric assessments over 6 months.
Although programmed cell death ligand 1 (PD-L1) is best known for its role in immune suppression, tumor-intrinsic functions are emerging. Here, we report that tumor cells that express PD-L1 are sensitive to ferroptosis inducers such as imidazole ketone erastin (IKE). PD-L1 promotes ferroptosis sensitivity because it suppresses SLC7A11 expression and diminishes glutathione levels.
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- Sleep plays a vital role in health and well-being, with many people experiencing sleep deprivation and chronic insomnia, leading to serious health issues.
- Understanding sleep architecture and hygiene is essential for maintaining physiological functions and overall homeostasis.
- The course targets certified registered nurse anesthetists, providing insights into the relationship between sleep and health, risk factors for chronic sleep deprivation, and treatment options like propofol-induced sleep.
Article Synopsis
- The study investigates the link between psychological readiness and physical recovery in patients who have undergone ACL reconstruction, noting that this relationship is not well understood.
- Researchers hypothesized that patients with greater psychological readiness would perform better in functional tests six months post-surgery.
- Their findings showed significant correlations between psychological readiness measures (like the ACL-RSI scale) and physical performance metrics, indicating that those who felt more psychologically prepared were likely to have better functional outcomes.
The high rate of recurrence after radiation therapy in triple-negative breast cancer (TNBC) indicates that novel approaches and targets are needed to enhance radiosensitivity. Here, we report that neuropilin-2 (NRP2), a receptor for vascular endothelial growth factor (VEGF) that is enriched on subpopulations of TNBC cells with stem cell properties, is an effective therapeutic target for sensitizing TNBC to radiotherapy. Specifically, VEGF/NRP2 signaling induces nitric oxide synthase 2 (NOS2) transcription by a mechanism dependent on Gli1.
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