[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].

While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.

[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].

The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted. It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries. Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced.

[Effect of deltaran on the mediatory balance in the brain of young and old rats with left-side laterality profile in case of carotid arteries occlusion].

The medico-social significance of ischemic brain lesions, which are the most frequent cause of disablement and death in older people, stipulates the need for efficient means of prevention and correction of central nervous system disorders in case of ischemic brain lesions. The efficacy of Deltaran in the correction of disordered neuromediator balance in the brain of rats of different age groups was studied on the model of carotid arteries occlusion. Studies showed, that Deltaran exerts an anti-stress effect on old rats with left-side profile by altering the neuromediators' distribution in animals' brain under conditions of hypoxia.

Adrenocortical and thyroid systems of rats during the initial period of nociceptive influences.

Two phases were identified in the initial period of formation of the adrenocortical reaction to acute nociception. The first phase (at 10-15 sec) consisted of an "urgent" mobilization of the " basal" reserves of hormonally active substances and was characterized by suppression of corticoliberin activity in the hypothalamus and extrahypothalamic brain structures in rats, with a parallel increase in the plasma concentration of adrenocorticotropic hormone, draining of corticosteroid reserves in the adrenals, and decreases in blood corticosterone levels on the background of increases in corticosterone levels in target organs. The second phase, the hypercompensation phase, involved progressive increases in the titers of study substances.

[Adrenocortical and thyroid systems of rats at the initial stage of nociceptive influence].

There are two phases in the initial period of formation of adrenocortical response to sharp nociceptive influence. The first phase (within 10-15 sec.) involves emergency mobilization of "basal" reserves of hormone active substances.