Achieving inter- and transdisciplinarity in Ecohealth: insights from a rodent-borne disease project in a polycrisis era.

Introduction: Inter- and transdisciplinary research (ITDR) is increasingly promoted to address "wicked problems", particularly in health sectors adopting approaches like Ecohealth. Our Ecohealth-inspired project on rodent-borne diseases, initiated just before the COVID-19 pandemic, provided an opportunity to evaluate ITDR implementation.

Methods: We employed a recently developed semi-quantitative evaluation method to measure our project's success in achieving ITDR and analyzed factors influencing this achievement.

An acute bout of 4 x 4-minute or 10 x 1-minute HIIT improves beta cell glucose sensitivity in post-menopausal females with type 2 diabetes: a secondary analysis.

Improvements in glycemic control following acute exercise are typically attributed to improved post-exercise insulin sensitivity (IS) with comparatively little known about how acute exercise impacts beta cell function, especially in post-menopausal females. We determined how two high-intensity interval training (HIIT) protocols, matched for total estimated energy expenditure, impact beta cell function in post-menopausal females with type 2 diabetes. Thirteen post-menopausal females (70 ± 5 years; 12 ± 7 years since diagnosis, 80.

How outsourcing has contributed to England's social care crisis.

argue that growth of private provision in adult social care in England has resulted in worse care and should be rolled back

Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer's disease.

Introduction: Sodium phenylbutyrate and taurursodiol (PB and TURSO) is hypothesized to mitigate endoplasmic reticulum stress and mitochondrial dysfunction, two of many mechanisms implicated in Alzheimer's disease (AD) pathophysiology.

Methods: The first-in-indication phase 2a PEGASUS trial was designed to gain insight into PB and TURSO effects on mechanistic targets of engagement and disease biology in AD. The primary clinical efficacy outcome was a global statistical test combining three endpoints relevant to disease trajectory (cognition [Mild/Moderate Alzheimer's Disease Composite Score], function [Functional Activities Questionnaire], and total hippocampal volume on magnetic resonance imaging).

Fluid Biomarkers in Individuals at Risk for Genetic Prion Disease up to Disease Conversion.

Objectives: To longitudinally characterize disease-relevant CSF and plasma biomarkers in individuals at risk for genetic prion disease up to disease conversion.

Methods: This single-center longitudinal cohort study has followed known carriers of pathogenic variants at risk for prion disease, individuals with a close relative who died of genetic prion disease but who have not undergone predictive genetic testing, and controls. All participants were asymptomatic at first visit and returned roughly annually.