Clinico-pathological factors associated with radioiodine refractory differentiated thyroid carcinoma status.

Purpose: Risk factors for developing radioiodine refractory thyroid cancer (RAIR-TC) have rarely been analyzed. The purpose of the present study was to find clinical and pathological features associated with the occurrence of RAIR-disease in differentiated thyroid cancers (DTC) and to establish an effective predictive risk score.

Methods: All cases of RAIR-DTC treated in our center from 1990 to 2020 were retrospectively reviewed.

Association of intracluster correlation measures with outcome prevalence for binary outcomes in cluster randomised trials.

In cluster randomised trials, a measure of intracluster correlation such as the intraclass correlation coefficient (ICC) should be reported for each primary outcome. Providing intracluster correlation estimates may help in calculating sample size of future cluster randomised trials and also in interpreting the results of the trial from which they are derived. For a binary outcome, the ICC is known to be associated with its prevalence, which raises at least two issues.