Publications by authors named "A M Martinez-Sapina"
Article Synopsis
- Chronic hepatitis D (CHD) affects about 5% of hepatitis B patients in Spain, with a significant portion having pre-existing conditions like cirrhosis and coinfections.
- A study involving 329 patients revealed that 62% tested positive for HDV-RNA and that persistence of this viremia is linked to faster liver disease progression, with one-third already having cirrhosis at diagnosis.
- Key challenges in managing these patients include delays in accessing new antiviral treatments and difficulties in accurately assessing HDV-RNA levels locally.
Background & Aims: Hepatitis C virus (HCV) interferes with carbohydrate and lipid metabolism causing cardiovascular disease and insulin resistance (IR). Direct-acting antivirals (DAAs) are highly effective for the eradication of HCV, with positive effects on metabolic health although paradoxically associated with increased total and LDL-cholesterol. The aims of this study were 1) to characterize dyslipidemia (lipoprotein content, number, and size) in naive HCV-infected individuals and 2) to evaluate the longitudinal association of metabolic changes and lipoparticle characteristics after DAA therapy.
View Article and Find Full Text PDFBackground: Hepatitis C virus (HCV) produces changes at multiple levels in host metabolism, especially in lipid profile and cardio-metabolic risk. It is unclear how HCV eradication by direct-acting antivirals (DAAs) modifies those changes.
Objective: To evaluate the impact of DAA treatment on different risk factors associated with cardiovascular disease.
Article Synopsis
- Circulating recombinant forms (CRFs) play a significant role in the HIV-1 pandemic, with 16 identified BF intersubtype recombinants primarily from South America, notably CRF12_BF.
- A new BF recombinant cluster found in Bolivia is now recognized as a part of a larger cluster of 39 viruses from multiple countries, especially Spain, Bolivia, and Peru, demonstrating diverse origins and connections.
- Genetic analyses identified a new CRF, named CRF89_BF, which likely emerged in Bolivia around 1986 and is the fifth member related to CRF12_BF, underscoring the complex nature of HIV-1 evolution in the region.