Publications by authors named "A M Maillard"
Microorganisms hosted in abiotic structures have led to engineered living materials that can grow, sense, and adapt in ways that mimic biological systems. Although porous structures should favor colonization by microorganisms, they have not yet been exploited as abiotic scaffolds for the development of living materials. Here, porous ceramics are reported that are colonized by bacteria to form an engineered living material with self-regulated and genetically programmable carbon capture and gas-sensing functionalities.
View Article and Find Full Text PDFAcute respiratory failure in adult patients with acute myeloid leukemia.
Expert Rev Respir Med
December 2024
Introduction: Patients with acute myeloid leukemia (AML) are at high risk of developing life-threatening complications. It is estimated that a quarter of adult patients diagnosed with AML will require admission to the intensive care unit (ICU) at least once during their disease. Acute respiratory failure (ARF) is the main reason for ICU admission and is associated with high mortality rates, depending on the etiology of ARF.
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- The study investigates the changes in gray matter (GM) volume in the insula, a brain region linked to addiction, comparing severe alcohol use disorder (sAUD) and severe cocaine use disorder (sCUD).
- Researchers analyzed 12 subregions of the insula using a sample of 50 sAUD patients, 61 sCUD patients, and 36 healthy controls, finding overall lower insula volume in both disorders, particularly in the anterior long gyrus (ALG).
- The results highlight both shared and distinct patterns of insula volume deficits between sAUD and sCUD, suggesting that while the insula is important in substance use disorders, each disorder may have unique characteristics that could inform treatment approaches.
Article Synopsis
- HIV infection increases the risk of diffuse large B-cell lymphoma (DLBCL), and this study analyzed B-cell activating cytokines and T cell subsets in 51 HIV-associated DLBCL patients undergoing R-CHOP treatment.
- R-CHOP therapy led to decreased IL-10 and fluctuating IL-6 levels while BAFF levels initially rose and then fell; a significant increase in naïve B cells was observed, but recovery of other B cell types was gradual.
- With a median follow-up of 41 months, 5-year progression-free survival was 61.8% and overall survival was 67.4%, with main causes of death being disease progression and sepsis, highlighting the need for assessing B-cell disturbances in patient
Article Synopsis
- Immune effector cell-associated neurotoxicity syndrome (ICANS) is a serious complication of CD19-targeted CAR T-cell therapy, and early prediction of patients at risk is crucial for tailored management.
- Elevated serum neurofilament light chain (NfL) levels are linked to the severity of ICANS, with higher levels indicating greater neuroaxonal injury.
- In a study of 150 patients, those with elevated NfL (>75 pg/mL at leukapheresis or >58 pg/mL at infusion) were significantly more likely to develop severe ICANS, suggesting that NfL could be a vital predictive marker for neurotoxicity in CAR T-cell therapy.