Publications by authors named "A M Madiehe"
Article Synopsis
- Matrix metalloproteinases (MMPs) are important in chronic wounds and are considered key therapeutic targets for treatment.
- This study utilized computational methods to explore how phytoconstituents from Ehretia species interact with MMP2 and MMP9, identifying 46 potential inhibitors among 74 compounds.
- Notable compounds like lithospermic acid B, rosmarinic acid, and others showed strong binding affinities, suggesting that these phytoconstituents could be promising candidates for developing new treatments for chronic wounds.
Wound healing effects of biogenic gold nanoparticles synthesized using red wine extracts.
Artif Cells Nanomed Biotechnol
December 2024
Gold nanoparticles (AuNPs) were synthesized using three red wine extracts (RW-Es); by varying temperature, pH, concentrations of RW-Es and gold salt. The RW-AuNPs were characterized by UV-vis, transmission electron microscopy (TEM), dynamic light scattering (DLS), and the Fourier Transform Infra-red Spectroscopy (FT-IR). Their stability was evaluated in water, foetal bovine serum (FBS), phosphate-buffered saline (PBS), and Dulbecco's Modified Eagle Medium (DMEM) by UV-Vis.
View Article and Find Full Text PDFMetabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease, is a steatotic liver disease associated with metabolic syndrome (MetS), especially obesity, hypertension, diabetes, hyperlipidemia, and hypertriglyceridemia. MASLD in 43-44% of patients can progress to metabolic dysfunction-associated steatohepatitis (MASH), and 7-30% of these cases will progress to liver scarring (cirrhosis). To date, the mechanism of MASLD and its progression is not completely understood and there were no therapeutic strategies specifically tailored for MASLD/MASH until March 2024.
View Article and Find Full Text PDFEbola viral disease (EVD) is a highly infectious and potentially fatal illness with a case fatality rate ranging from 25% to 90%. To effectively control its spread, there is a need for rapid, reliable and lowcost point-of-care (P OC) diagnostic tests. While various EVD diagnostic tests exist, few are P OC tests, and many are not cost-effective.
View Article and Find Full Text PDFArticle Synopsis
- * Drug discovery and development are essential but often complex, costly, and lengthy processes, prompting the pharmaceutical industry to seek innovative approaches to streamline these efforts.
- * Computer-aided drug discovery (CADD) is a promising technology that offers faster, cheaper, and more efficient routes to identify and develop new drug candidates, with successful case studies demonstrating its potential in tackling AMR.