Publications by authors named "A M MacLeod"

We are pleased to present our Special Issue on Participatory Research. In this editorial, we outline how the disability rights movement has been instrumental to the development of participatory approaches, before giving consideration to some of the debates and criticisms associated with participatory research in practice. We summarise the contributions offered by the studies within this issue and propose four areas of consideration, drawn from the body of included research, to inform future developments.

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Article Synopsis
  • Dynamic assessment can serve as a diagnostic tool and broaden its application as a curriculum-based measure to observe teaching moments and intervention elements in speech sound disorder treatment.
  • The study used the Glaspey Dynamic Assessment of Phonology to analyze teaching moments and children's skill development among two boys with speech sound disorders, while noting differences in treatment outcomes.
  • Results showed that dynamic assessment effectively tracked progress during treatment and suggested a need for further research to establish clearer goals, indicating its potential to enhance both assessment and intervention strategies.
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Aberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin-associated periodic syndrome (CAPS), neurodegenerative diseases, gouty arthritis, and numerous others. Hence, there has been an increasing interest in NLRP3 inhibitors as therapeutics. A first generation of NLRP3 inhibitors bearing a sulfonylurea core such as MCC950 (developed by Pfizer) were discovered by phenotypic screening, however their mode of action was only elucidated later.

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  • Schistosomiasis is a widespread disease in Côte d'Ivoire, and a study compared the conventional Kato Katz (KK) test with the more sensitive point-of-care circulating cathodic antigen (POC-CCA) test to improve control strategies for intestinal schistosomiasis.
  • A survey involving 554 schoolchildren from eight elementary schools found that the prevalence of intestinal schistosomiasis was significantly higher when using the POC-CCA (67%) compared to the KK test (10%), highlighting the need for more effective diagnostic methods.
  • Activities such as swimming and fishing were linked to higher infection rates, indicating a strong association between lifestyle choices and schistosomiasis prevalence, suggesting the necessity for targeted interventions.
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  • A six-year-old spayed female Siberian Husky presented with cervical pain, ataxia, respiratory changes, and significant weight loss, leading to a battery of diagnostic tests.
  • Findings indicated serious health issues, including spinal myelopathy and signs suggestive of metastatic carcinoma, prompting humane euthanasia and further investigation through necropsy.
  • The necropsy revealed multiple tumors consistent with cholangiocellular carcinoma, highlighting challenges in prior diagnostics and an unusual presentation with cervical pain likely linked to spinal metastasis.
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