Publications by authors named "A M M Labate"
Objective: Temporal lobe epilepsy (TLE) is the most common form of refractory focal epilepsy, and the current clinical diagnosis is based on EEG, clinical neurological history and neuroimaging findings.
Methods: So far, there are no blood-based molecular biomarkers of TLE to support clinical diagnosis, despite the pathogenic mechanisms underlying TLE involving defects in the regulation of gene expression. MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression.
Article Synopsis
- * A multicenter study reanalyzed the effectiveness of LEV vs. LTG, revealing that LTG had significantly lower treatment failure rates and better medication retention than LEV.
- * Both medications had similar safety profiles, and while there were no notable differences in achieving total seizure freedom, LTG showed a strong likelihood of being superior for overall treatment effectiveness.
Background And Purpose: 'Dancing-like' semiology is extremely rare and described in few case reports. It is characterized by rhythmic, oscillatory movements of the pelvis and/or limbs during which the subject appears to be dancing. It has been associated with both the frontal and temporal epileptic zone; however, the possible network involved in these fascinating seizures is unclear.
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- The study aimed to identify factors that predict seizure recurrence in women of childbearing age with idiopathic generalized epilepsy (IGE) who switched from valproate (VPA) to alternative antiseizure medications (ASMs) like levetiracetam (LEV) and lamotrigine (LTG).
- Researchers evaluated data from 426 women across 16 epilepsy centers, finding that common reasons for switching medications included concerns about teratogenicity and that around a quarter of the women experienced worsening or recurrence of seizures within 12 and 24 months.
- The analysis revealed that LEV was associated with a lower risk of seizure recurrence or worsening compared to LTG, providing potential guidance for treatment options after VPA discontinuation.