Evaluation of adherence to a daily progestin-only pill in a simulated over-the-counter setting.

Objective: The Adherence with Continuous Dose Oral Contraceptive: Evaluation of Self-Selection and Use (ACCESS) study assessed whether consumers can adhere to the regimen for a progestin-only pill (norgestrel 0.075 mg) in an over-the-counter (OTC) setting.

Study Design: An actual use study in a simulated OTC environment assessed adherence to directions to take norgestrel 0.

Evaluation of consumer self-selection of a proposed over-the-counter, progestin-only daily oral contraceptive.

Objectives: In an effort to switch a norgestrel 0.075 mg progestin-only pill (Opill) from prescription to over-the-counter, we conducted this study to assess whether consumers can use the drug facts label alone to guide appropriate self-selection.

Study Design: Two studies assessed self-selection: (1) an all-comers, actual-use study evaluating self-selection before purchasing and using norgestrel 0.

Modeling the potential benefit of an over-the-counter progestin-only pill in preventing unintended pregnancies in the U.S.

Objectives: To develop a model to estimate the possible impact of use of an over-the-counter (OTC) progestin-only pill (POP) on the number of unintended pregnancies in the United States.

Study Design: Using typical use failure rates (7% for POPs), we compared the expected number of unintended pregnancies for two theoretical cohorts of 100,000 women: one which purchased and used an OTC POP exclusively for contraception, the other using contraceptive methods at proportions obtained from an actual-use clinical trial simulating OTC use of norgestrel 0.075 mg (including 35% using no method and only 19% using hormonal contraception or long-acting contraceptives).

The views of women and pharmacists on the desirability of a progestogen-only pill over the counter. Results of a survey in Germany, Italy and Spain.

Purpose: To explore the perceived need and enthusiasm for over the counter (OTC) progestogen-only pills (POP).

Materials And Methods: A web-based survey of 1000 sexually active women (16-45) and 100 pharmacists in Germany, Italy and Spain.

Results: Despite not wanting to conceive, 5-6% of women in each country were not using contraception and 8-20% were using methods less effective than condoms.

The effect of deliberate non-adherence to a norgestrel progestin-only pill: A randomized, crossover study.

Objectives: To estimate the effects on cervical mucus, ovarian activity and theoretical contraceptive protection of a 6-hour delay and of missing one norgestrel 0.075 mg progestogen-only pill.

Study Design: In a prospective, two-site, randomized, crossover study, healthy women aged 18 to 35 with BMI <32.