Publications by authors named "A M Llorente"
In p53-deficient cancers, targeting cholesterol metabolism has emerged as a promising therapeutic approach, given that p53 loss dysregulates sterol regulatory element-binding protein 2 (SREBP-2) pathways, thereby enhancing cholesterol biosynthesis. While cholesterol synthesis inhibitors such as statins have shown initial success, their efficacy is often compromised by the development of acquired resistance. Consequently, new strategies are being explored to disrupt cholesterol homeostasis more comprehensively by inhibiting its synthesis and intracellular transport.
View Article and Find Full Text PDF: Alzheimer's dementia is a progressive neurodegenerative disease that affects memory abilities due to genetic and environmental factors. A well-known gene that influences the risk of Alzheimer's disease is the apolipoprotein E (APOE) gene. The APOE gene is involved in the production of a protein that helps transport cholesterol and other types of fat in the bloodstream.
View Article and Find Full Text PDFUnlabelled: Women with breast cancer (BC) experience multiple symptoms related to neoadjuvant chemotherapy (NAC) treatment that impair their functioning and quality of life (QoL). This study aimed to explore the effect of high-intensity aerobic interval training (HIIT) on quality of life and NAC side effects in women with BC.
Methods: 56 patients (48.
Introduction: Lymphocele is a common complication post-kidney transplantation, influenced by various factors including surgical technique, graft vessel count, operator experience, body mass index, ischemia time, and immunotherapy regimens.
Project Aims: The purpose of this study was to evaluate lymphocele risk factors, particularly focusing on the role of end-stage kidney disease.
Design: A retrospective study was conducted on renal transplant recipients from a single center (March 2020 to December 2022).
Article Synopsis
- The study evaluated how effective a screening program for liver fibrosis is in reducing alcohol consumption among individuals with alcohol use disorder (AUD) at the Hospital Clinic of Barcelona.
- Out of 334 individuals screened, 45% were abstinent from alcohol after 6 months, significantly higher than the 29% abstinence rate in a control group.
- Key factors promoting abstinence included receiving medication for AUD, no illicit drug use, and participation in the screening program, highlighting the benefits of early diagnosis and lifestyle counseling.