Publications by authors named "A M Lepagnol-Bestel"
Article Synopsis
- Optimizations in immunotherapy for Triple-negative breast cancer (TNBC) show promise, particularly in targeting galectin-9 (Gal-9) after radiotherapy.
- In TNBC patients receiving neoadjuvant radiotherapy, higher Gal-9 levels were observed in non-responders compared to baseline, indicating a potential link between Gal-9 expression and treatment response.
- A study in mice showed that targeting Gal-9 with an antibody led to reduced tumor growth only in those injected with irradiated cancer cells, suggesting Gal-9's potential as a biomarker and therapeutic target in TNBC.
Article Synopsis
- Schizophrenia (SZ) is a complex mental disorder influenced by genetics, and researchers analyzed a large set of genomic data to identify dysfunctional brain networks related to the condition.
- They identified three overlapping subclusters linked to microtubule function, the actin cytoskeleton, and synaptic transmission, and examined de novo mutations in SZ patients from Algeria, France, and Japan.
- The study found specific mutations associated with protein functions crucial for the cytoskeleton and transport, and animal experiments indicated that one gene variant led to brain structure issues, suggesting avenues for future therapeutic research.
Article Synopsis
- Down syndrome (DS) is linked to trisomy of human chromosome 21 and features intellectual disability, studied through two mouse models with extra gene copies.
- RNA analysis showed different gene expression patterns tied to chromatin and synaptic functions in each model, while a large-scale protein interaction study found numerous connections to intellectual disability-related genes.
- Key proteins from chromosome 21 were found at crucial synaptic sites, revealing potential links between Down syndrome, autism risk genes, and other brain disorders like Alzheimer's disease.
Brain diseases such as autism and Alzheimer's disease (each inflicting >1% of the world population) involve a large network of genes displaying subtle changes in their expression. Abnormalities in intraneuronal transport have been linked to genetic risk factors found in patients, suggesting the relevance of measuring this key biological process. However, current techniques are not sensitive enough to detect minor abnormalities.
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