Publications by authors named "A M Lazaris"
Food safety is a key priority for public health. However, consumer demand for cheese products may expose the population to the risk of mycotoxicosis and cancer, among others. Acute mycotoxicosis and cancer are examples of linked disorders.
View Article and Find Full Text PDFBackground: Ensuring food safety is a fundamental priority for public health. The catering sector has become prominent as a convenient and cost-effective method of food supply worldwide. Adherence to proper food hygiene practices is crucial for preventing foodborne diseases.
View Article and Find Full Text PDFBackground/aim: Significant transcription factors - including c-Fos (gene locus: 14q24.3) and c-Jun (gene locus: 1p32-p31) - regulate cell homeostasis preventing abnormal signal transduction to nucleus. Their over-activation seems to be associated with an aggressive phenotype in non-small cell lung carcinomas (NSCLCs).
View Article and Find Full Text PDFOlaparib monotherapy in advanced triple-negative breast cancer patients with homologous recombination deficiency and without germline mutations in BRCA1/2: The NOBROLA phase 2 study.
Breast
December 2024
Article Synopsis
- The study aimed to assess the effectiveness of olaparib in patients with advanced triple negative breast cancer who have homologous recombination deficiency but do not have BRCA1/2 mutations.
- The NOBROLA trial was conducted as a phase IIa study, enrolling patients treated with olaparib, and focused on the clinical benefit rate as the main measurement.
- Out of 114 patients screened, only 6 were eligible; the median follow-up was 8.5 months, showing a clinical benefit rate of 50%, suggesting potential for further research.