Publications by authors named "A M La Greca"
Article Synopsis
- * An analysis of ATMPs in Italy from 2016 to 2023 shows that while 9 of 18 authorized ATMPs are reimbursed by the Italian National Health System, only 6 have been used, leading to an expenditure of about 300 million euros, primarily due to CAR-T therapies.
- * Patient access to ATMPs takes an average of 340.6 days after reimbursement decisions, but since 2016, availability and treatment coverage have improved, with most regions having at least one authorized center for administering
MEN2 phenotype in a family with germline heterozygous rare RET K666N variant.
Endocrinol Diabetes Metab Case Rep
July 2024
Article Synopsis
- MEN2 is a hereditary cancer syndrome linked to mutations in the RET proto-oncogene, with MEN2A being the most common form, involving risks for medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism.
- The specific RET variant K666N is rare, and most associated patients generally present with a mild form of medullary thyroid cancer; however, one case showed more severe symptoms including pheochromocytoma.
- A reported case involves a young proband who developed severe complications post-surgery, revealing a RET K666N variant alongside pheochromocytoma, medullary thyroid cancer, and primary hyperparathyroidism, indicating it may have low penetrance in MEN
Central venous access devices are essential for the management of critically ill patients, but they are potentially associated with many complications, which may occur during or after insertion. Many evidence-based documents-consensus and guidelines-suggest practical recommendations for reducing catheter-related complications, but they have some limitations. Some documents are not focused on critically ill patients; other documents address only some special strategies, such as the use of ultrasound; other documents are biased by obsolete concepts, inappropriate terminology, and lack of considerations for new technologies and new methods.
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- Acute cholecystitis is a common surgical condition that can range from mild to severe, with a mortality rate of 10-20% when accompanied by bacteremia.
- Early laparoscopic cholecystectomy is the preferred treatment, while alternative options like percutaneous cholecystostomy may be used for select cases.
- Antibiotic therapy is essential for preventing complications and controlling inflammation, with choices depending on various factors like infection severity, timing, and drug resistance, emphasizing the importance of antibiotic stewardship in treating bile-related infections.
Background: Thyroid cancer has an overall favorable prognosis, but no pre-operative biochemical marker has been shown to distinguish between low and high-risk disease or predict response to therapy.
Methods: We retrospectively reviewed 162 patients that underwent thyroid surgery for thyroid cancer between 2006 and 2022 in whom a pre-operative thyroglobulin level (Tg) was measured. We subdivided patients into low, intermediate and high-risk thyroid cancer and based on their response to therapy per ATA guidelines.