Publications by authors named "A M L N van Ommen"
Underrepresentation of women in cardiovascular disease clinical Trials-What's in a Name?
Int J Cardiol Heart Vasc
December 2024
Background: Cardiovascular disease is the leading cause of death in women worldwide. Yet, women are often underrepresented in cardiovascular clinical trials. Trial characteristics may influence the participation of women.
View Article and Find Full Text PDFComplex health challenges require professionals to operate across disciplines and to better connect with society. Here, we showcase a community-engaged and challenge-based educational model in which undergraduate students conduct transdisciplinary research on authentic complex biomedical problems. This concept reinforces translational medicine, human capital, and exemplifies synergy between education, research, healthcare, and society.
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- - The study examines the relationship between kidney function and echocardiography findings related to left ventricular diastolic dysfunction (LVDD) in patients from a university hospital, categorizing them by levels of kidney function based on estimated glomerular filtration rate (eGFR).
- - Among 4,022 patients, those with increasingly decreased kidney function showed higher odds of having abnormal echocardiographic parameters, including the E/e' ratio and left ventricular mass index (LVMI), indicating a clear connection between deteriorating kidney health and worsening cardiac function.
- - The findings reveal that even mildly decreased kidney function is associated with signs of LVDD, suggesting that as kidney function declines, the risk of echocardiographic abnormalities in
Circulating proteins may provide insights into the varying biological mechanisms involved in heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). We aimed to identify specific proteomic patterns for HF, by comparing proteomic profiles across the ejection fraction spectrum. We investigated 4210 circulating proteins in 739 patients with normal (Stage A/Healthy) or elevated (Stage B) filling pressures, HFpEF, or ischemic HFrEF (iHFrEF).
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- The study examines how kidney dysfunction correlates with left ventricular diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), focusing on whether these associations differ between sexes.
- Data was collected from 880 participants, revealing that those with mild to moderate kidney dysfunction had significantly higher rates of HFpEF compared to those with normal kidney function, along with elevated measures of heart function.
- The findings suggest that both mild and moderate kidney dysfunction are major risk factors for HFpEF, with the strongest link found in moderate dysfunction, indicating the need for early intervention in at-risk groups.