Publications by authors named "A M Kullaa"
are ubiquitous fungal organisms that colonize the oral cavity of healthy individuals without causing disease. is an opportunistic microorganism with several virulent factors that influence the inflammatory process and allow it to invade tissues, evade host defense mechanisms, and release toxins, facilitating proliferation and degradation. At present, increasing emphasis is placed on polymicrobial interactions between and various bacterial pathogens.
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- The study reviewed recent literature on the connection between oral diseases, particularly periodontitis, and cognitive neurodegenerative diseases like Alzheimer's.
- The research highlighted significant links especially in older adults who have other risk factors, showing worse oral health correlating with higher neurodegenerative disease risk.
- It concluded that maintaining good oral health might help prevent or lessen the risks associated with neurodegenerative diseases.
Short-chain fatty acids (SCFAs) are the metabolites identified in both the oral cavity and the gut. They play an important role in the triggering, development and progression of systemic diseases. SCFAs can alter the gut microbial components, intestinal epithelium and host immune system, and are also associated with cancer incidence.
View Article and Find Full Text PDFIn recent years, salivary metabolome studies have provided new biological information and salivary biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected in the salivary metabolite profile. Oral microbes can alter the salivary metabolite profile and may express oral inflammation or oral diseases.
View Article and Find Full Text PDFObjectives: The present preliminary study aimed to investigate the salivary metabolic profile in patients with asymptomatic oral lichen planus (OLP) using nuclear magnetic resonance (NMR) spectroscopy.
Material And Methods: Stimulated whole mouth saliva (SWMS) samples were collected from 15 reticular OLP female patients and 15 from age- and sex-matched controls (HCs). A total of 23 metabolites were identified and quantified.