Basic Science and Pathogenesis.

Background: Changes in neuroinflammatory tone have been shown to modulate neuroimmune responses to Alzheimer's disease (AD) pathology and shape disease outcomes, however, extrinsic factors that modify neuroimmune activation remain poorly understood. The gut microbiome is one such factor, with the ability to shape peripheral and central immune activation, as well as AD pathologies. AD patients display unique changes in microbiome composition, however, the link between specific AD-associated gut bacteria, neuroinflammatory tone, and AD outcomes remains to be elucidated.

The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.

Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behavior, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons, and the remaining 5% are GABAergic and cholinergic interneurons.

Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation.

The objective of this study is to develop a universally applicable approach for establishing the optimal dose range for the irradiation of plant and animal products. The approach involves the use of the optimization function for establishing the optimal irradiation dose range for each category of plant and animal product to maximize the suppression of targeted pathogens while preserving the surrounding molecules and biological structures. The proposed function implies that pathogens found in the product can be efficiently suppressed provided that irradiation is performed with the following criteria in mind: a high irradiation dose uniformity, a high probability of irradiation hitting pathogens and controlled heterogeneity of radiobiological sensitivity of pathogens.

[Correction of the effect of vitamin K antagonists and antiplatelet agents in hemorrhagic stroke].

Background: Hemorrhagic stroke (HS) is associated with high risk of mortality or disability. To date, up to 25% of HSs are associated with anticoagulants and antiplatelet agents. Early hemostatic therapy and correction of effect of antithrombotic drugs in patients with HS significantly reduce the risk of adverse outcomes.

[Decolonization of autologous blood with cefuroxime during hardware reinfusion in neurosurgical patients].

Unlabelled: Autologous blood obtained during hardware reinfusion can be bacterially contaminated with skin microflora in most cases (up to 90%) regardless of the area of surgical intervention. Increased volume of washing solution for red blood cell management, white blood cell filtration and X-ray irradiation do not always provide complete decontamination.

Objective: To analyze the effectiveness of adding cefuroxime to extracorporeal circuit during hardware blood reinfusion.