Platelet aggregability during the first two years of type 1 (insulin-dependent) diabetes mellitus in children.

Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with those in 44 health control children.

Early changes of some serum proteins and metals in diabetic children.

Serum concentrations of prealbumin, albumin, orosomucoid, magnesium, zinc and calcium were studied in 30 children with newly diagnosed IDDM aged 3-15 years, during the first two years of the disease, and in 44 healthy control children. On admission serum prealbumin was significantly lower in IDDM children (149 +/- 48 mg/l) (M +/- SD) than in healthy controls (194 +/- 39 mg/l) (p less than 0.001).

Impaired vascular reactivity during the first two years of diabetes mellitus after initial restoration.

Vascular reactivity was studied prospectively in 36 consecutive children (15 males, 21 females) below 15 years from the county of Uppsala with newly acquired type I diabetes mellitus (IDDM). Skin postocclusive hyperaemia was recorded with a transcutaneous oxygen electrode at 37 degrees C on admission before receiving insulin treatment and 1, 6, 12 and 24 months after diagnosis. Fifty-eight healthy children (25 males, 33 females), served as a reference group.