Publications by authors named "A M Kluska"
Article Synopsis
- The study retrospectively evaluated the effectiveness of ultra-low dose rate brachytherapy (uLDR-BT) in 39 patients with unfavorable intermediate risk prostate cancer, despite current guidelines recommending against it due to insufficient evidence.
- Results showed a promising median follow-up of about 56 months, with an 87.02% biochemical failure-free survival rate, indicating uLDR-BT could be a viable treatment option.
- No significant differences in outcomes were observed based on additional risk factors or treatment methods, suggesting that uLDR-BT's effectiveness is consistent across different patient profiles in the intermediate risk category.
Article Synopsis
- This study investigates the microbiomes of the oral cavity, esophagus, and stomach using different sampling methods in patients with varying risks for esophageal cancer, specifically esophageal squamous cell carcinoma (ESCC).
- Researchers analyzed samples from 11 patients with pre-cancerous conditions, 21 head and neck cancer survivors, and 40 individuals with functional dyspeptic symptoms, using advanced genetic sequencing techniques.
- Findings indicate significant differences in microbial diversity and composition across the different patient groups, particularly between functional dyspepsia patients and cancer survivors, but note that the relationship between microbiota changes and treatments for head and neck cancer is still unclear.
The key association between gut dysbiosis and cancer is already known. Here, we used whole-genome shotgun sequencing (WGS) and gas chromatography/mass spectrometry (GC/MS) to conduct metagenomic and metabolomic analyses to identify common and distinct taxonomic configurations among 40, 45, 71, 34, 50, 60, and 40 patients with colorectal cancer, stomach cancer, breast cancer, lung cancer, melanoma, lymphoid neoplasms and acute myeloid leukemia (AML), respectively, and compared the data with those from sex- and age-matched healthy controls (HC). α-diversity differed only between the lymphoid neoplasm and AML groups and their respective HC, while β-diversity differed between all groups and their HC.
View Article and Find Full Text PDFBackground: The study investigated the impact of starch degradation products (SDexF) as prebiotics on obesity management in mice and overweight/obese children.
Methods: A total of 48 mice on a normal diet (ND) and 48 on a Western diet (WD) were divided into subgroups with or without 5% SDexF supplementation for 28 weeks. In a human study, 100 overweight/obese children were randomly assigned to prebiotic and control groups, consuming fruit and vegetable mousse with or without 10 g of SDexF for 24 weeks.
Background: Possible relationships between gut dysbiosis and breast cancer (BC) development and progression have been previously reported. However, the results of these metagenomics studies are inconsistent. Our study involved 88 patients diagnosed with breast cancer and 86 cancer-free control women.
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