Publications by authors named "A M Karkar"
Article Synopsis
- The study explores how different diets affect weight and metabolism in genetically diverse mouse strains, highlighting that individual genetic makeups influence these responses.
- Mice were subjected to various humanized diets (American, Mediterranean, vegetarian, and vegan), revealing significant variations in body weight, triglyceride, and insulin levels based on both diet and genetic strain.
- Specifically, around 400 genes related to metabolism responded differently to diets in various strains, suggesting that while genetics strongly influences metabolism, dietary choices also play a crucial role, paving the way for research into personalized nutrition for humans.
Article Synopsis
- * Key research includes the efficacy of respiratory syncytial virus vaccinations, various COPD therapies like dupilumab and lung volume reduction strategies, and the impact of positive-pressure ventilation on patients with sleep disorders and recent strokes.
- * Additional studies cover the combination therapy of rituximab and mycophenolate mofetil for nonspecific interstitial pneumonia and updated clinical recommendations for evaluating pleural disorders, along with a review of inhaled corticosteroids in COPD treatment.
The practice and clinical outcomes of peritoneal dialysis (PD) have demonstrated significant improvement over the past 20 years. The aim of this review is to increase awareness and update healthcare professionals on current PD practice, especially with respect to patient and technique survival, patient modality selection, pathways onto PD, understanding patient experience of care and use prior to kidney transplantation. These improvements have been impacted, at least in part, by greater emphasis on shared decision-making in dialysis modality selection, the use of advanced laparoscopic techniques for PD catheter implantation, developments in PD connecting systems, glucose-sparing strategies, and modernising technology in managing automated PD patients remotely.
View Article and Find Full Text PDFPurpose: Corticosteroids are now recommended for patients with severe COVID-19 including those with COVID-related ARDS. This has generated renewed interest regarding whether corticosteroids should be used in non-COVID ARDS as well. The objective of this study was to summarize all RCTs examining the use of corticosteroids in ARDS.
View Article and Find Full Text PDFBackground: The role of maintenance therapy in transplant ineligible multiple myeloma (MM) patients following a period of fixed duration induction therapy remains unclear.
Objectives: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) examining maintenance therapy compared to observation.
Methods: We conducted a comprehensive search including MEDLINE, Embase, and the Cochrane database up to February 28, 2020, for RCTs comparing maintenance therapy to observation in newly diagnosed transplant ineligible MM patients.