Safety of Gadopiclenol After Its First Year of Clinical Use.

Gadopiclenol is a novel, macrocyclic high-relaxivity gadolinium-based contrast agent recently approved for use in magnetic resonance imaging of the central nervous system and body organs at a dose of 0.05 mmol/kg body weight. Postmarketing surveillance of its first year of clinical use in the United States of America showed no serious adverse events (AEs) following over 882,550 administrations and a very low rate of nonserious AEs (1 case every 27,580 exposures).

Metal Nanoclusters for Interface Engineering and Improved Photovoltaic Performance in Organic Solar Cells.

Copper nanoclusters (Cu NCs), synthesized by a one-pot synthesis method, were theoretically shown to exhibit a dipole moment and cause work function modification on a surface as observed from Kelvin probe measurement. Here, Cu NCs were used as an interfacial modifier in organic solar cells (OSCs). The effective engineering of the electron transporting layer/active layer interface using Cu NCs resulted in improved photovoltaic performance in fullerene and non-fullerene based OSCs.

Prevalence of TB-related symptoms and self-reported disability among adult TB survivors.

Background: Growing evidence suggests that post-TB-related morbidity occurs often among TB survivors, but there is limited epidemiological data on the burden of symptoms and disability after successful completion of treatment. We evaluated the prevalence of TB-related symptoms, self-reported disability, and factors associated with disability among adult TB survivors who recently completed treatment in Uganda.

Methods: Between January 2022 and October 2023, we conducted a study of adults who completed treatment for drug-susceptible TB in Kampala, Uganda.

Intraclass Correlation in Cluster Randomized Controlled Trials: A Meta-Analysis of Studies on Major Depression.

Background: Though cluster randomized trials (CRTs) provide robust evidence for intervention by controlling contamination of interventions, there could be some loss of statistical efficiency. The Consolidated Standards of Reporting Trials (CONSORT) recommends reporting intraclass correlation coefficients (ICC) to understand this phenomenon, though not many studies follow this. This meta-analysis explored the compliance of CRTs in major depression for reporting ICC besides deriving the pooled ICC and pooled mean differences of intervention outcomes.