Publications by authors named "A M Jarabek"
The use of new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the specifics of exposure methods and cell/tissue-based test systems. This topic was examined in the context of human health risk assessment for cleaning products at a 1-day public workshop held on 2 March 2023, organized by the American Cleaning Institute (ACI). The goals of this workshop were to (1) review NAMs for evaluation of respiratory irritation, (2) examine different perspectives on current challenges and suggested solutions, and (3) publish a manuscript of the proceedings.
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- The National Nanotechnology Initiative held a Nanoinformatics Conference in 2023, discussing collaborations between the U.S. and EU on handling nanotechnology data.
- They talked about creating databases, their pros and cons, and how to improve standards for sharing and storing information about nano Environmental Health and Safety (nanoEHS).
- Important topics that were missed include evaluating data usage, including community input, and integrating new data types like micro and nano plastics for better future progress.
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- Standard information reporting is essential for consistent assay conditions and data, enabling easier comparisons between laboratories.
- The publication presents the Minimum Information for Reporting on the TEER assay (MIRTA), a key method used to assess cell culture models and toxicity potential.
- Developed through an international collaboration, the recommendations from the RespTox Collaborative aim to improve data transparency, reproducibility, and quality in both respiratory and other cell systems.
Geothermal features, such as hot springs and mud volcanoes, host diverse microbial life, including many extremophile organisms. The physicochemical parameters of the geothermal feature, such as temperature, pH, and heavy metal concentration, can influence the alpha and beta diversity of microbial life in these environments, as can spatiotemporal differences between sites and sampling. In this study, water and sediment samples were collected and analyzed from eight geothermal sites at Yellowstone National Park, including six hot springs, a mud volcano, and an acidic lake within the same week in July 2019, and these geothermal sites varied greatly in their temperature, pH, and chemical composition.
View Article and Find Full Text PDFNew approach methodologies (NAMs) are emerging chemical safety assessment tools consisting of in vitro and in silico (computational) methodologies intended to reduce, refine, or replace (3R) various in vivo animal testing methods traditionally used for risk assessment. Significant progress has been made toward the adoption of NAMs for human health and environmental toxicity assessment. However, additional efforts are needed to expand their development and their use in regulatory decision making.
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