Post-traumatic stress disorder (PTSD) symptom clusters associated with an indicator of heart rate variability: The ADVANCE cohort study.

Background: Heart rate variability (HRV) is governed by of sympathetic and parasympathetic regulatory systems. Post-Traumatic Stress Disorder (PTSD) may influence these systems and consequently affect cardiovascular functioning.

Methods: The sample consisted of 860 UK male military personnel approximately half of who had sustained physical combat injuries in Afghanistan.

Benefits and durability of an affordable prosthetic silicone cushion liner locally manufactured in a resource-limited environment: Enabling adoption of total surface bearing sockets and silicone cushion liners.

Introduction: Prosthetic silicone liners improve comfort and skin protection and allow the use of total surface bearing (TSB) sockets, which provide enhanced proprioception and comfort. Unfortunately, silicone liners are cost-prohibitive in resource-limited environments (RLEs) where patellar tendon bearing (PTB) sockets with PE-lite liners remain standard, leading to patient discomfort and skin issues.

Objective: This study evaluates the benefits and durability of an affordable silicone liner locally manufactured in an RLE to promote TSB socket adoption, aiming to enhance prosthetic care and patient outcomes.

Cytokine storm in a massively burned pediatric patient.

Cytokine storm can occur in many different clinical conditions and lack of recognition can lead to death. While cytokines have been measured and trended in burn patients, cytokine storm has not been widely discussed or its treatment reported. We present herein the diagnosis and the treatment of a 5-year-old, 91% burn patient, who developed cytokine storm three times during his hospital course.

Bone remodeling simulation using spatial influence function in macroscopic cube case.

Bone has the capability to adapt its density in response to mechanical stimuli through a process known as bone remodeling, which has been simulated using various algorithms in several studies, with Strain Energy Density (SED) being a commonly used driving parameter. A spatial influence function has been introduced in addition to the remodeling algorithm, which accounts for the influence of neighboring regions on local mechanical stimuli, thereby reducing artificial mesh dependency and mimicking cellular communication in bone. However, no study has implemented the SED-driven algorithm with spatial influence function on a macroscopic 3D bone structure, and there is no physiological explanation on the value used in remodeling parameter.