Publications by authors named "A M Hutchins"
Epigenetic control of cell fates is a critical determinant to maintain cell type stability and permit differentiation during embryonic development. However, the epigenetic control mechanisms are not well understood. Here, it is shown that the histone acetyltransferase reader protein BRD8 impairs the conversion of primed mouse EpiSCs (epiblast stem cells) to naive mouse ESCs (embryonic stem cells).
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- Vulvovaginal candidiasis (VVC) is a common infection with a high recurrence rate, defined as having four or more episodes in a year, which poses significant clinical challenges.
- In this study, researchers analyzed vaginal samples from 31 recurrent VVC patients, 28 VVC patients, and 29 healthy women, finding similarities in symptoms but noting increased swelling in the VVC group.
- The analysis revealed changes in the vaginal microbiota, including decreased beneficial bacteria and increased bacteria associated with bacterial vaginosis, highlighting the potential role of metabolites like L-glutamate in recurring infections, which may inform future treatment strategies.
Microbes found in soil can have a significant impact on the taste and quality of wine, also referred to as wine terroir. To date, wine terroir has been thought to be associated with the physical and chemical characteristics of the soil. However, there is a fragmented understanding of the contribution of vineyard soil microbes to wine terroir.
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- Endogenous retroviruses (ERVs) are significant components of the human genome, with some influencing immune response and early development.
- The study identifies a specific ERV, ERVH48-1, that plays a crucial role in somatic development by affecting mesoderm and cardiomyocyte differentiation during early embryonic stages.
- ERVH48-1 operates by degrading the WNT antagonist SFRP2, which helps regulate WNT/β-catenin signaling pathways, ultimately impacting cell type commitment.