Publications by authors named "A M Huisman"
Background: Genetic selection improves a population by increasing the frequency of favorable alleles. Understanding and monitoring allele frequency changes is, therefore, important to obtain more insight into the long-term effects of selection. This study aimed to investigate changes in allele frequencies and in results of genome-wide association studies (GWAS), and how those two are related to each other.
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- - Kisspeptin plays a crucial role in regulating gonadotropin secretion in pigs, and a study was conducted on F1 pigs from a parental line created by CRISPR/Cas9 knockout of the KISS1 gene, which eliminates the need for castration.
- - The research measured body weights, gonadotropin levels, and reproductive development in these pigs, finding that while body weight didn't differ based on genotype, KISS1-/- boars and gilts exhibited significantly reduced gonadotropin concentrations and experienced hypogonadism.
- - The results suggest that only one functional KISS1 allele is necessary for normal gonadal function and hormone secretion, and that the knockout of KISS1 does