Assessing Microsatellite Variations in Plasmodium falciparum Following a Decade-Long Antimalaria Campaign in Kenya.

Anti-malaria interventions typically reduce the intensity of Plasmodium transmission, but the effects of reduced transmission on P. falciparum population biology remain unclear. Highly polymorphic microsatellite markers in P.

Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh.

Shorter telomere length (TL) is associated with an increased risk for developing chronic or age-related diseases in adults. The process of telomere shortening is accelerated in response to stress and is well characterized in adult populations from high-income countries. Prior studies suggest the relationship between stress, shorter TL, and disease risk initiates in early life.

Identifying Informal Help-Seeking Patterns in African American Couples.

While African American couples are less likely to seek formal resources, such as couples therapy, that does not mean they do not seek relationship support. The literature suggests that informal or community resources play a large role in supporting African American couples. Yet, up to this point, quantitative research has yet to identify specific factors that increase informal couple help-seeking for African Americans.

Prognostic adjustment with efficient estimators to unbiasedly leverage historical data in randomized trials.

Although randomized controlled trials (RCTs) are a cornerstone of comparative effectiveness, they typically have much smaller sample size than observational studies due to financial and ethical considerations. Therefore there is interest in using plentiful historical data (either observational data or prior trials) to reduce trial sizes. Previous estimators developed for this purpose rely on unrealistic assumptions, without which the added data can bias the treatment effect estimate.

Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy.

Background: Glioblastoma (GBM) carries a poor prognosis, and new therapeutic strategies are necessary to improve outcomes for patients with this disease. Alkylating chemotherapies including temozolomide (TMZ) and lomustine (CCNU) are critical for treating GBM, but resistance mechanisms, including hypomethylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter, undermine treatment. CRISPRoff is a programmable epigenetic memory editor that can induce stable and heritable gene silencing after transient delivery, and we hypothesize that CRISPRoff could potentiate the activity of TMZ and CCNU through long term suppression of target genes.