Background: The effect of isotretinoin on muscle is considered to be uncommon and benign. We analyzed the files of all our patients given isotretinoin over a 5-year period and determined the incidence and gravity of its effect on muscles.
Materials And Methods: Sixty treatments with isotretinoin were studied.
Therapeutic monitoring of 8-methoxypsoralen (8-MOP) was studied in 12 patients (age range 43-85 years, weight range 48-76 kg) treated for Sezary's syndrome by extracorporeal photochemotherapy (ECP) for 14-41 months. Before the beginning of each ECP cycle (2 sessions on consecutive days at about 4-week intervals), a blood sample was drawn to determine the 8-MOP plasma concentration 2 h after drug ingestion. Plasma 8-MOP levels were measured using a high-performance liquid chromatography method with spectrophotometric detection.
View Article and Find Full Text PDFPhotodermatol Photoimmunol Photomed
April 1992
Extracorporeal photochemotherapy (ECPC) requires ex vivo UVA irradiation of blood lymphocytes during the time of the theoretical peak 8-methoxsalen (8-MOP) concentration. The aims of this study were to determine the mechanism of cellular uptake of 8-MOP, its possible saturation and the time needed to reach maximal concentration (Tmax) in lymphoid cells. 8-MOP was measured by liquid chromatography in the supernatant of lymphoid cell suspensions incubated with a known amount of 8-MOP.
View Article and Find Full Text PDFAnn Dermatol Venereol
August 1988
We report two new cases of neurotrophic ulceration of the trigeminal nerve associated with Wallenberg syndrome, and we present the six cases published since the first description of the neurologic syndrome, in 1895. This peculiar etiology supports the argument for the dominant physiopathologic hypothesis: ulcerations due to multiple microtraumatisms caused by the thermoalgic anesthesia.
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