Beyond Microbial Variability: Disclosing the Functional Redundancy of the Core Gut Microbiota of Farmed Gilthead Sea Bream from a Bayesian Network Perspective.

The significant microbiota variability represents a key feature that makes the full comprehension of the functional interaction between microbiota and the host an ongoing challenge. To overcome this limitation, in this study, fish intestinal microbiota was analyzed through a meta-analysis, identifying the core microbiota and constructing stochastic Bayesian network (BN) models with SAMBA. We combined three experiments performed with gilthead sea bream juveniles of the same hatchery batch, reared at the same season/location, and fed with diets enriched on processed animal proteins (PAP) and other alternative ingredients (NOPAP-PP, NOPAP-SCP).

Small Extracellular Vesicles Derived from Cord Blood Plasma and Placental Mesenchymal Stem Cells Attenuate Acute Lung Injury Induced by Lipopolysaccharide (LPS).

Sepsis is a risk factor associated with increasing neonatal morbidity and mortality, acute lung injury, and chronic lung disease. While stem cell therapy has shown promise in alleviating acute lung injury, its effects are primarily exerted through paracrine mechanisms rather than local engraftment. Accumulating evidence suggests that these paracrine effects are mediated by mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs), which play a critical role in immune system modulation and tissue regeneration.

Effect of overnight bladder drainage on posterior urethral valve sequelae: A randomized controlled trial.

Introduction: Posterior urethral valves may lead to persistent hydronephrosis (HN) and bladder dysfunction despite successful endoscopic valve ablation (EVA).

Objectives: To evaluate the effect of overnight bladder drainage (OBD) on upper urinary tracts and bladders of boys post EVA.

Materials And Methods: Boys who had persistent HN after EVA were included.

Evaluation of pain intensity and airway changes in non-growing patients treated by MARPE with and without micro-osteoperforation: a randomized clinical trial.

Trial Design: Parallel.

Objectives: To assess the effect of mini-screw assisted rapid palatal expansion (MARPE) with/without micro-osteoperforation (MOP) on the airway and pain intensity in non-growing patients with maxillary transverse deficiency.

Method: Two equal groups of twenty-four individuals aged ≥ 19 years old with maxillary transverse deficit were randomly assigned.

X-ray guided anatomy-based fitting: The validity of OTOPLAN.

Background: Anatomy-based fitting (ABF) for cochlear implant users is a new era that seeks improved outcomes. Recently, different imaging modalities, such as plain X-rays, have been proposed to build the ABF as an alternative to the computed tomography (CT) scan. This study aimed to assess the feasibility and validity of OTOPLAN® software in building ABF using plain X-ray imaging.