Publications by authors named "A M Fulghesu"
Objective: This study aimed to determine the prevalence of polycystic ovarian morphology (PCOM) in healthy postmenarcheal girls and assess whether it represents a crucial physiological phase in gynecological development. Additionally, it evaluated if an elevated stromal-to-surface area (S/A) ratio could identify individuals at risk of developing polycystic ovarian syndrome (PCOS).
Design: This is an observational cross-sectional study.
Article Synopsis
- This text discusses a consensus on the use of inositols, particularly myo-inositol (Myo), for treating reproductive disorders in women, with a focus on those with polycystic ovary syndrome (PCOS).
- A panel of endocrinologists and a gynecologist evaluated how Myo can help with menstrual irregularities, fertility, pregnancy outcomes, and neonatal health, resulting in eight consensus statements.
- The findings suggest Myo can improve certain reproductive issues but highlight the need for more research to clarify its effectiveness, proper dosage, and the potential benefits of combining it with D-chiro-inositol.
MicroRNAs (miRNAs) are small, non-coding RNAs that are essential for the regulation of post-transcriptional gene expression during tissue development and differentiation. They are involved in the regulation of manifold metabolic and hormonal processes and, within the female reproductive tract, in oocyte maturation and folliculogenesis. Altered miRNA levels have been observed in oncological and inflammatory diseases, diabetes or polycystic ovary syndrome (PCOS).
View Article and Find Full Text PDFThe identification of insulin resistance and hyperinsulinemia in polycystic ovary syndrome (PCOS) is not a minor issue. The homeostasis model assessment of insulin resistance index (HOMA) is the most used index of IR (Insulin Resistance), validated in overweight and obese patients but not in normal-weight PCOS subjects, who can still present with increased insulin secretion by an oral glucose tolerance test (OGTT). The evaluation of insulin secretion and resistance represents a still unresolved problem.
View Article and Find Full Text PDFPolycystic Ovarian Morphology in Normocyclic Non-hyperandrogenic Adolescents.
J Pediatr Adolesc Gynecol
October 2021
Objective: To understand whether polycystic ovarian morphology (PCOM) represents a transient phase, and whether an increased stroma could help to characterize the phenotype of the ovary in adolescence.
Methods: Cross-sectional population-based study on high-school students in Cagliari, Italy. The study population consisted of 257 normocyclic non-hyperandrogenic girls selected from a sample of 600 healthy volunteers recruited from 2012 to 2016.