Publications by authors named "A M Freije"
High-intensity focused ultrasound (HIFU) is a non-invasive therapeutic modality that uses precise acoustic energy to ablate cancerous tissues through coagulative necrosis. In this context, we investigate the efficacy of HIFU ablation in two distinct cellular configurations, namely 2D monolayers and 3D spheroids of epithelial breast cancer cell lines (MDA-MB 231 and MCF7). The primary objective is to compare the response of these two in vitro models to HIFU while measuring their ablation percentages and temperature elevation levels.
View Article and Find Full Text PDF: HIV infection is a global public health problem that can lead to the progression of AIDS. Nutritional status and biochemical markers can significantly contribute to the progression of AIDS in HIV/AIDS patients. The main objective of this study is to examine the association between nutritional and biochemical markers as well as BMI in HIV/AIDS patients in the kingdom of Bahrain.
View Article and Find Full Text PDFThis study aimed to analyze the fatty acid content in human milk and to find its relationship with the growth velocity of preterm infants. Mature milk samples from 15 mothers of preterm infants were collected from three different hospitals, followed by lipid extraction, fatty acid methylation, and finally gas chromatography analysis to determine the fatty acids composition. The average total lipid content was 3.
View Article and Find Full Text PDFBackground: Vitamin D deficiency has reached pandemic levels in the Middle East and North Africa (MENA) region, even though sunshine is abundant all year round for the cutaneous synthesis of vitamin D through the skin. This study aimed to determine the prevalence of vitamin D deficiency and risk factors associated with serum 25-hydroxy vitamin D (25(OH)D) in children and adolescents aged from 10 to 19 years, as well as the possible associations of vitamin D with calcium, magnesium and phosphate levels.
Methods: A multi-center, cross-sectional study was conducted between May and August 2019 at the Ministry of Health in the Kingdom of Bahrain.
Article Synopsis
- Epithelial transdifferentiation, like squamous metaplasia (SQM), often occurs in tissue hyperplasia and can lead to diseases, with SQM being a precursor to aggressive lung cancer but less common in mammary glands.
- Research conducted on human lung and mammary cells reveals that exposure to genotoxic drugs, such as Doxorubicin and carcinogens like DMBA, can trigger SQM and polyploidization, suggesting a link between DNA damage and this cellular change.
- Enhancing DNA repair or inhibiting specific mitotic checkpoints reduces the extent of SQM, highlighting potential targets for treatments aimed at lung squamous cell carcinoma and explaining the frequency of SCC in the