Publications by authors named "A M Flinn"
Introduction: Chimeric antigen receptor T cells (CAR-Ts) targeting CD19 represent a significant advance in treatment for patients with relapsed/refractory B-cell malignancies. Although a significant minority of recipients are women during their reproductive years, there is a paucity of data regarding pregnancy and neonatal outcomes in women previously treated with CAR-T. This is important as maternal T cells are known to cross the placenta and into breastmilk during pregnancy and breastfeeding, respectively.
View Article and Find Full Text PDFUpdate on hereditary C1q deficiency: pathophysiology, clinical presentation, genotype and management.
Curr Opin Allergy Clin Immunol
December 2024
Purpose Of Review: C1q deficiency is a rare inborn error of immunity characterized by susceptibility to severe infections and profound immune dysregulation, with a systemic lupus erythematosus-like phenotype. The management of patients with C1q deficiency is challenged by the rarity of this condition and the wide clinical variability. This review aims to emphasize the importance of a thorough immunological and clinical characterization to help guide a personalized and comprehensive approach to patients.
View Article and Find Full Text PDFArticle Synopsis
- - C1q deficiency is a rare immune disorder that increases the risk of infections and autoimmune diseases similar to systemic lupus erythematosus (SLE), often leading to various health complications.
- - An international study involving 18 patients evaluated the outcomes of hematopoietic stem cell transplantation (HSCT) for C1q deficiency, showing a 71% overall survival rate and improvement in autoimmune symptoms for most patients.
- - The study highlights that patients with severe autoimmune symptoms have poorer survival rates, and specific antibodies were linked to different organ involvements, emphasizing the need for careful patient selection and risk assessment for HSCT as a treatment option.
Article Synopsis
- Congenital athymia is a serious condition that affects the immune system and makes babies very sick because their thymus (an important organ for immunity) doesn't work properly.
- Babies with this condition are very vulnerable to infections and sometimes have other health issues.
- The best treatment is a special surgery called thymus transplantation, and catching this condition early helps kids stay healthier.