Clinical Implementation of a High-Throughput Automated Comprehensive Genomic Profiling Test: TruSight Oncology 500 HT.

The adoption of comprehensive genomic profiling in oncology has rapidly increased the demand for standardized tumor sample processing in diagnostic laboratories. Automation of DNA and RNA library preparation workflows offers the possibility to scale-up and standardize sample processing. We report on the clinical implementation of the automated TruSight Oncology 500 High-Throughput library preparation workflow from formalin-fixed, paraffin-embedded tumor samples using the Biomek i7 hybrid Workstation.

Changes in hippocampal volume and affective functioning after a moderate intensity running intervention.

This study examined the effects of a moderately intense seven-week running intervention on the hippocampal volume and depressive symptoms of young men (20-31 years of age) from the general population (N = 21). A within-subjects-design involving a two-week baseline period before the running intervention, and two subsequent intervention cycles was applied. At four time points of assessment (t: start of the study; t: end of baseline period/start of the intervention; t: end of the first intervention cycle; t: end of the 2nd intervention cycle/study end) magnetic resonance imaging was performed and symptoms related to depression were assessed employing the Center for Epidemiological Studies Depression (CES-D) Scale.

Dementia and risks of temperature-related mortality and hospitalizations in Germany.

Background: Extreme temperatures are associated with negative health outcomes, in particular for older adults with pre-existing conditions. While climate change is expected to increase exposure to temperature levels that are detrimental for health, little is known about how dementia shapes vulnerability to extreme temperatures.

Methods: We leveraged repeated quarterly individual-level health claims from 2004 to 2019 on 250,000 individuals in Germany aged 50 years and above with information on key neurodegenerative diseases such as dementia.

Depression Symptoms Do Not Worsen Over Time in a Cohort of CKD Patients: The BRINK Study.

Background: The prevalence of depression is high in the chronic kidney disease (CKD) (20-40%) and dialysis (30-50%) populations. Less is known about how depressive symptoms change over time in patients with CKD.

Methods: Participants in the Brain in Kidney Disease (BRINK) cohort study completed a depressive symptom questionnaire (PHQ-9) and serum creatinine testing annually.

Habitual physical activity is related to more creative activities and achievements.

Beyond health, physical activity (PA) is associated with better creative ideation performance. People who are habitually more physically active produce more original ideas when asked to think creatively about an alternative use of an everyday object such as a brick. This aligns with findings indicating a positive relationship of PA with more basic cognition, such as memory, attention, as well as executive functioning.