Publications by authors named "A M Fietta"
The zebrafish (Danio rerio) is a valuable model organism for studying human biology due to its easy genetic manipulation and small size. It is optically transparent and shares genetic similarities with humans, making it ideal for studying developmental processes, diseases, and drug screening via imaging-based approaches. Solid malignant tumors often contain hypoxic areas that stimulate the release of extracellular vesicles (EVs), lipid-bound structures released by cells into the extracellular space, that facilitate short- and long-range intercellular communication and metastatization.
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- The 'QuantitatEVs' workshop focused on quantitative methods for analyzing extracellular vesicles (EVs), from large bulk samples to individual vesicles, emphasizing new technologies.
- * The event explored critical issues in analyzing EV-associated molecules and biophysical features, which are key for discovering and validating EV biomarkers for clinical use.
- * Held in Trento, Italy, from January 31 to February 2, 2023, the workshop included a follow-up event in Milan aimed at supporting early career researchers.
Background: Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. Albeit hypoxia and EVs release are known features of Neuroblastoma (NB), a metastasis-prone childhood malignancy of the sympathetic nervous system, whether hypoxic EVs can facilitate NB dissemination is unclear.
Methods: Here we isolated and characterized EVs from normoxic and hypoxic NB cell culture supernatants and performed microRNA (miRNA) cargo analysis to identify key mediators of EVs biological effects.
Article Synopsis
- The apple is a key global fruit crop and serves as a model for studying the evolution and domestication of crops that are grown for multiple seasons.
- Research using various scientific approaches has tracked the history and speed at which apples have been cultivated across Eurasia.
- Combining archeobotanical studies with genetics can reveal important traits that contributed to apple domestication, which could enhance modern apple breeding methods.
Objective: The pathophysiology of the lung fibrotic process in systemic sclerosis (SSc) is not fully elucidated. Since this pattern represents the leading cause of death in SSc, the knowledge of its actual pathophysiology is basic to prevent and stage pulmonary damage. In this study, we aimed to further investigate the relationship between the functional profiles of bronchoalveolar lavage (BAL) T cells and the pulmonary manifestation of the disease.
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