Publications by authors named "A M Ferretti"
Modulation of cerebellar-cortical connectivity induced by modafinil and its relationship with receptor and transporter expression.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Article Synopsis
- - Modafinil is used to treat narcolepsy and as a cognitive enhancer, impacting the connectivity of brain networks related to attention and executive function, with less known about its effects on subcortical areas.
- - In a study with 50 participants, researchers measured resting-state fMRI connectivity before and after a single dose of modafinil or a placebo, focusing on cerebellar-neocortical relationships and neurotransmitter receptor expression.
- - Results showed that modafinil enhanced connectivity in specific cerebellar regions (Crus I and Vermis IX) with prefrontal areas and other brain regions, linking these changes to the presence of dopaminergic and histaminergic receptors.
This review delves into the potential of manipulating the microbiome to enhance oral tolerance in food allergy, focusing on food allergen-specific immunotherapy (FA-AIT) and the use of adjuvants, with a significant emphasis on probiotics. FA-AIT, including oral (OIT), sublingual (SLIT), and epicutaneous (EPIT) immunotherapy, has shown efficacy in desensitizing patients and achieving sustained unresponsiveness (SU). However, the long-term effectiveness and safety of FA-AIT are still under investigation.
View Article and Find Full Text PDFEffectiveness and safety of polyethylene-glycol-4000 versus sodium picosulphate plus magnesium oxide and citric acid for bowel cleansing before colonoscopy in children: A systematic review with meta-analysis.
Silvia Furio Alessio Lucarini Maurizio Mennini Caterina Strisciuglio Enrico Felici Alessandro Ferretti
J Pediatr Gastroenterol Nutr
October 2024
Article Synopsis
- Colonoscopy is important for diagnosing and treating conditions, and effective bowel cleansing is crucial, but there's no standard preparation for children.
- A systematic review of six studies compared the effectiveness and safety of polyethylene glycol (PEG) and sodium picosulfate (SPMC) for this purpose, finding both to be effective.
- SPMC was generally preferred for its better acceptability and compliance, resulted in fewer instances of needing a nasogastric tube, and a split-dose preparation was found to be more effective than a day-before regimen.
Article Synopsis
- Developmental and epileptic encephalopathies (DEE) are disorders that can be caused by new mutations in a specific gene, leading to different symptoms, from severe conditions to milder ones like autism.
- A case study of a six-year-old boy showed he had a new mutation in that gene, but he did not develop epilepsy and had a normal brain scan over five years.
- This case helps us understand that not everyone with mutations in this gene will have serious problems, which is important for doctors to know when diagnosing developmental delays.