N-Aryl Benzimidazole and Benzotriazole Derivatives and Their Hybrids as Cytotoxic Agents: Design, Synthesis and Structure-Activity Relationship Studies.

The era of chemotherapy began in the 1940s, which is the basis of traditional antitumor approaches and, being one of the most high-tech treatment methods, is still widely used to treat various types of cancer. A promising direction in modern medicinal chemistry is currently the creation of hybrid molecules containing several pharmacophore fragments of different structures. This strategy is successfully used to increase the therapeutic efficacy of cytotoxic agents and reduce side effects.

Pseudo Four-Component Synthesis of 5,6-Dihydroindolo[2,1-]isoquinolines.

An easy synthesis of novel highly functionalized 5,6-dihydroindolo[2,1-]isoquinolines was developed via a pseudo four-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal α,β-ynones, and malononitrile. The selective formation of this biologically relevant heterocyclic core was achieved using a one-pot approach under microwave irradiation. The formation of the same skeleton through the reaction of 5,6-dihydropyrrolo[2,1-]isoquinolines with malonic acid dinitrile supports the proposed mechanism, involving the intermediate product of the three-component reaction.

A novel fluorescent sensor for diammonium and metal ions based on a supramolecular charge-transfer complex of bis(aza-18-crown-6)-containing dienone.

A bis(aza-18-crown-6)-containing 2,5-di(benzylidene)cyclopentanone and a bis(ammoniopropyl) derivative of 1,2-di(4-pyridyl)ethylene in MeCN were found to form a supramolecular charge-transfer complex, which can act as an "off-on" fluorescent sensor for the Ca and 1,12-dodecanediammonium ions. The molecular structure of this complex in solution was studied by density functional theory calculations.

Thermal Rearrangement of 5-(2-Hydroxy-6-oxocyclohexyl)-5-chromeno[2,3-]pyridines.

Some of the most important transformations in organic chemistry are rearrangement reactions, which play a crucial role in increasing synthetic efficiency and molecular complexity. The development of synthetic strategies involving rearrangement reactions, which can accomplish synthetic goals in a very efficient manner, has been an evergreen topic in the synthetic chemistry community. Xanthenes, pyridin-2(1)-ones, and 1,6-naphthyridines have a wide range of biological activities.

Solvent-Involved Synthesis of 5--Substituted 5-Chromeno[2,3-]pyridines.

Chromeno[2,3-]pyridines are substances demanded in medicinal and material chemistry. (pot, atom, and step economy) and in particular approaches are key green chemistry techniques that are applied for the synthesis of heterocyclic compounds. In this case, the approach was extended with 'component economy', as solvent was used also as reactant (solvent-involved reaction).