[The agreed experts' position of the Eurasian Association of Therapists on tactics of management of patients with comorbid pathology infected with SARS-Cov-2].

The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail.

[Age features of treatment of idiopathic membranoproliferative glomerulonephritis].

The aim of the study was to investigate the effectiveness of long application of the combined therapy by cytostatics and steroid hormones for patients with morphologically proved membranoproliferative glomerulonephritis depending on age. 51 patients younger 60 years and 27 patients older 60 years were investigated. Patients received therapy by steroid hormones and cytostatics within one year.

[Combined therapy of membranoproliferative glomerulonephritis in older patients].

The aim of the study was to investigate the effectiveness of combined long-term therapy by cytostatics and steroid hormones in older patients with membranoproliferative glomerulonephritis to halt renal failure progression. 27 patients older than 60 years with morphologically proved membranoproliferative glomerulonephritis have been treated. Nephrosclerosis was detected in 40% of studied patients according to results of kidney biopsies.

Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia.

Chronic renal failure was modeled in rats by partial nephrectomy. Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated. In rats treated with spironolactone, the index of myocardial hypertrophy did not considerably differ from that in sham-operated animals, whereas in untreated rats the test parameters considerably differ from the control.

[The characteristics of left ventricular myocardial remodeling in patients with chronic renal disease, and the effects of spironolactone therapy].

The work reflects modern concepts of the pathogenesis of myocardial and vascular remodelling in a chronic renal disease. Types of changes in left ventricular geometry and the condition of the diastolic function in patients at pre-dialysis stage of a chronic renal disease and patients on program hemodialysis. Dynamic changes in left ventricular parameters under the influence of therapy with spironolactone, an aldosterone receptor blocker, are described.