Social Determinants of Health Challenges Are Prevalent Among Commercially Insured Populations.

Objectives: To evaluate the prevalence of social determinants of health (SDoH) factors in a large commercially-insured population and to characterize the prevalence of common conditions (eg, diabetes, behavioral health issues) and addressable health services utilization concerns (eg, lack of preventive care) for which employers offer no- and low-cost benefit programs.

Methods: We identified groups with SDoH challenges within a commercially-insured population of 5.1 M through administrative data and self-report.

The importance of PET/CT in the evaluation of patients with Ewing tumors.

The effective evaluation for the treatment of patients with Ewing tumors depends on the accuracy in the determination of the primary tumor extent and the presence of metastatic disease. Currently, no universally accepted staging system is available to assess Ewing tumors. The present study aimed at discussing the use of PET/CT as a tool for staging, restaging and assessment of therapeutic response in patients with Ewing tumors.

[Epidemiology aspects of inflammatory bowel disease in the east region of Minas Gerais State].

Inflammatory bowel disease is an umbrella term used to describe Crohn's disease and ulcerative colitis. Both diseases are correlated but show distinct clinical aspects. Epidemiological studies were conducted in order to describe the knowledge production in intestinal inflammatory disease taking into consideration the registered of hospital internments in the east of Minas Gerais State.

A global benchmark study using affinity-based biosensors.

To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times.

Nogo-A expression after focal ischemic stroke in the adult rat.

Background And Purpose: The Nogo-A protein is an important inhibitor of axonal remodeling after central nervous system injuries, including ischemic stroke. Interfering with the function of Nogo-A via infusion of a therapeutic anti-Nogo-A antibody after stroke increases neuronal remodeling and enhances functional recovery in rats. In this study, we describe the regional distribution of cortical neurons expressing Nogo-A in normal rats and following middle cerebral artery occlusion (MCAO).