Publications by authors named "A M Dygaĭ"
We studied the effect of reprogrammed CD8 T cells (rT cells) from the bone marrow of intact mice on tumor cells and neovasculogenesis in mice with orthotopic Lewis lung carcinoma (LLC). Reprogramming of T cells was carried out using a MEK inhibitor and a PD-1 blocker; the targeting of rT cells to tumor cells was achieved by preincubation with LLC cell lysate. It was shown that the antitumor effect of rT cells was based on apoptosis of tumor cells.
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- The study investigates how dark deprivation influences liver health and circadian rhythms when exposed to carbon tetrachloride (CCl), a known hepatotoxic agent.
- While much is known about CCl's effects on the liver, research on its impact within the context of circadian rhythms is limited, and many studies focus on isolated periods rather than the overall rhythm.
- Findings suggest that dark deprivation leads to more severe structural and functional liver changes due to reduced melatonin levels, indicating the need for further research on the role of melatonin in these processes.
Article Synopsis
- * Mice received a single dose of dibornol at varying levels, while rats were given a lower dose before and after treatment with cytostatic drugs like methotrexate and doxorubicin.
- * The results showed dibornol did not have a genotoxic effect and significantly decreased spontaneous DNA damage in the bone marrow, as well as reduced DNA breaks caused by the cytostatic drugs.
Background: Awareness of age-related features of carcinogenesis and the importance of cellular immunity is crucial for developing effective antitumor therapies for specific patient groups.
Methods: In this study, we examined different populations of cancer stem cells (CSCs) and circulating tumor cells (CTCs) in "young" (8-10 weeks) and "aged" (80-82 weeks) C57BL/6 male mice. We used an orthotopic model of Lewis lung carcinoma (LLC) to evaluate the effectiveness of cell therapy targeting lung cancer through reprogrammed CD8-positive T cells (rCD8+ T cells) in mice from two different ages.
Article Synopsis
- The study examined the effects of the dopamine D2 receptor antagonist spiperone on combined lung conditions—emphysema and lung cancer—in C57BL/6 mice.
- Results indicated that spiperone reduced lung inflammation, tumor size, and metastasis, along with decreasing the number of cancer stem cells (CSCs) in both the lungs and blood of treated mice.
- The findings suggest that targeting dopamine D2 receptors could be a viable strategy for treating lung cancer in patients suffering from emphysema.