Publications by authors named "A M Damask"
Purpose: This analysis investigated potential associations between gene variants and clinical end points in the VIEW 1 and 2 randomized clinical trials of intravitreal aflibercept and ranibizumab in neovascular age-related macular degeneration (AMD).
Methods: A genome-wide association analysis was conducted in a subgroup of patients from VIEW 1 and 2 consenting to the optional pharmacogenetic analysis.
Results: Data were pooled from 780 samples from patients representative of the overall VIEW 1 and 2 populations.
Article Synopsis
- The study investigates the potential benefits of inhibiting PCSK9, a protein, to improve the clearance of bacteria from the bloodstream and enhance outcomes in sepsis treatment.
- Researchers used genetic studies, a clinical trial analysis, and experimental animal models to explore the relationship between PCSK9 inhibition and sepsis mortality.
- Results showed a correlation in human cohorts between PCSK9 loss-of-function variants and lower sepsis mortality rates, while the clinical trial indicated low frequency of sepsis events among participants treated with alirocumab, a PCSK9 inhibitor.
Article Synopsis
- The Mexico City Prospective Study is a large-scale research initiative involving over 150,000 adults from urban areas in Mexico City, aimed at understanding genetic diversity and ancestry.
- The study reveals a mix of Indigenous American, European, and African ancestries among participants, highlighting significant genetic differences and a unique genetic landscape within the Indigenous Mexican population.
- Researchers created a valuable reference panel for genetic research, improving the accuracy of studying genetic variants in populations with high Indigenous ancestry, and providing essential resources for future genetic studies in both Mexico and the US.