Prognostic significance of cytokine dysregulation in critically ill COVID-19 patients.

Background: Understanding the immunopathogenesis of COVID-19 has yielded valuable insights into predicting adverse outcomes-particularly mortality. However, significant gaps persist in our comprehension of the complex interplay among the proposed pathophysiological mechanisms. Here, we aim to investigate the immunological factors associated with mortality in critically ill, unvaccinated COVID-19 patients admitted to the intensive care unit (ICU).

Between-day variability of soleus H reflex recruitment curve parameters: how many stimulations are required to maximise the reproducibility of the measurements?

Purpose: The H reflex recruitment curve represents the gold standard for quantifying changes in spinal circuitries. However, there is no agreement on how many stimulations should be applied for each parameter. Thus, we explored the impact of varying the number of stimulations (3, 6, 9, 12 and 15 stimuli per intensity) on between-day reliability of soleus H reflex.

Syndemic, mental health and living with dependent persons in Latin America and Spain: a study with a gender perspective.

Objective: To analyze the sociostructural determinants associated with mental health problems during the lockdown period among populations residing in Brazil, Chile, Ecuador, Mexico, Peru, and Spain who lived with minors or dependents, approached from a gender perspective.

Methods: A cross-sectional study was conducted in six participating countries via an adapted, self-managed online survey. People living with minors and/or dependents were selected.

Screening Wild Birds for Tick-Borne Zoonotic Pathogens in Portugal.

Wild birds may be involved in the transmission of agents of infectious diseases, including zoonoses, a circumstance which raises a number of public and animal health issues. Migratory bird species play a significant role in the introduction of tick-borne pathogens to new geographic areas, contributing to the dissemination of various etiological agents. This preliminary study aimed to assess the occurrence of four potentially zoonotic pathogens ( spp.

7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats.

Ovarian cancer has the highest mortality rate of all gynecological cancers. Animal models using 7,12-dimethylbenz(a)anthracene (DMBA) have been developed to investigate the mechanisms of ovarian carcinogenesis. The present study is a systematic review of efforts to establish DMBA as a model for ovarian cancer induction in rat models.