Global emergency medicine: A scoping review of the literature from 2023.

Objective: The Global Emergency Medicine Literature Review (GEMLR) highlights the highest-quality research addressing emergency care in resource-limited settings (ECRLS). This 18th edition reviews global emergency medicine (GEM) literature published during 2023.

Methods: A scoping review of GEM articles published in 2023 was performed using a systematic PubMed search and manual gray literature (GRAY) search.

'I think it's wrong, but it helps' - a focused ethnography of benzodiazepine practices in specialist palliative care.

Benzodiazepines are a class of drug extensively used in palliative care. Their use has predominantly been studied within a biomedical framework. Our study instead focused on the sociocultural aspects of benzodiazepine practices.

Scaling factors to inform - extrapolation from preclinical and livestock animals: state of the field and recommendations for development of missing data.

The use of - physiologically based pharmacokinetic (IVIVE-PBPK) modeling approaches assists for prediction of first-in animal or human trials. These approaches are underpinned by the scaling factors: microsomal protein per gram (MPPG) and cytosolic protein per gram (CPPG). In addition, IVIVE-PBPK has significant application in the reduction and refinement of live animal models in research.