Publications by authors named "A M Cimini"
Background: While magnetic resonance imaging (MRI) remains the gold standard for morphological imaging, its ability to differentiate between tumor tissue and treatment-induced changes on the cellular level is insufficient. Notably, glioma cells, particularly glioblastoma multiforme (GBM), demonstrate overexpression of chemokine receptor-4 (CXCR4). This study aims to evaluate the feasibility of non-invasive Ga-Cixafor™ PET/CT as a tool to improve diagnostic accuracy in patients with high-grade glioma.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2D) is defined by chronic hyperglycemia due to insufficient insulin secretion or activity and decreased insulin sensitivity, known as insulin resistance (IR). This condition leads to oxidative stress and inflammation, increasing the risk of systemic inflammatory diseases. Obesity and a sedentary lifestyle are major risk factors for IR and T2D.
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- The central nervous system (CNS) relies on the interaction between glial cells and neurons for essential functions like development, communication, and maintaining brain health.
- Glial cells, such as astrocytes and microglia, play a crucial role in neuroinflammation during brain disorders and can either promote or inhibit inflammation through their responses to brain damage.
- Extracellular vesicles (EVs) released by glial cells are key in mediating communication and responses in neuroinflammatory conditions, impacting neurodegenerative diseases by either exacerbating or alleviating toxic effects on neurons.
Legumes, rich in protein, fiber, and micronutrients, are increasingly popular in pulse-based and gluten-free foods despite global consumption stagnating at 21 g/day due to taste, low protein digestibility, anti-nutrients, and long cooking times. Bean resistance to cooking causes textural defects like the hardshell and hard-to-cook phenomena. The pectin-cation-phytate hypothesis explains why soaking beans in sodium salts reduces cooking time by enhancing pectin solubility in water.
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- A study compared different types of PET scans, focusing on a new scan called Ga-FAPI-46 to see how well it detects cancer compared to a regular scan called F-FDG.
- Eleven patients with various cancers, like colon and breast cancer, were examined using different types of PET scans.
- The results showed that Ga-FAPI-46 was better at finding cancer spread in areas like lymph nodes and bones compared to F-FDG.