Publications by authors named "A M Cacace"
Article Synopsis
- This study investigates how Type 2 diabetes mellitus (T2D) impacts the vestibular and balance systems in humans, highlighting that the majority of those affected have T2D.
- It utilizes various forms of evidence (epidemiological, anatomical, etc.) to show that higher blood glucose levels and longer disease duration lead to greater balance dysfunction, including an increased risk of vertigo and diminished vestibular compensation.
- The findings suggest that managing blood glucose through diet, medication, and exercise can help alleviate the negative effects of diabetes on balance and vestibular functions.
This minireview explores the burgeoning field of targeted protein degradation (TPD) and its promising applications in neuroscience and clinical development. TPD offers innovative strategies for modulating protein levels, presenting a paradigm shift in small-molecule drug discovery and therapeutic interventions. Importantly, small-molecule protein degraders specifically target and remove pathogenic proteins from central nervous system cells without the drug delivery challenges of genomic and antibody-based modalities.
View Article and Find Full Text PDFEfficacy of antepartum fetal surveillance for stillbirth prevention.
J Matern Fetal Neonatal Med
December 2024
Article Synopsis
- The study investigates the impact of antepartum fetal surveillance (AFS) on stillbirth rates in women with risk factors during a five-year period at a healthcare institution.
- It analyzed data from 16,827 deliveries, finding that stillbirth rates were similar between women who underwent AFS and those who did not (1.8‰ vs. 2.3‰).
- The findings suggest that AFS could potentially lower stillbirth risk in high-risk pregnancies to levels comparable to low-risk pregnancies as recommended by ACOG.
The mite Varroa destructor Anderson and Trueman (Mesostigmata: Varroidae) has a dramatic impact on beekeeping and is one of the main causes of honey bee colony losses. This ectoparasite feeds on honey bees' liquid tissues, through a wound created on the host integument, determining weight loss and a reduction of lifespan, as well as the transmission of viral pathogens. However, despite its importance, the mite feeding strategy and the host regulation role by the salivary secretions have been poorly explored.
View Article and Find Full Text PDFArticle Synopsis
- Tau acetylation at lysine 174 is linked to neurodegenerative diseases like Alzheimer's, FTLD, and TBI, and targeting it could improve cognitive function.
- In a study using PS19 mice, treatment with anti-ac-tauK174 antibodies reduced tau pathology and improved neurobehavioral outcomes, even after TBI.
- Results showed that anti-ac-tauK174 not only mitigated memory impairment and neurodegeneration but also altered gene expression in brain cells, indicating its potential as a therapeutic approach for tau-related conditions.