Publications by authors named "A M C Kastelein"
Background: Inflammation has been reported to drive cancer-related fatigue (CRF). As both obesity and chemotherapy promote inflammatory responses, obese cancer patients may be at risk of more severe CRF, especially when receiving chemotherapy.
Methods: We analysed data of 333 colon cancer patients from four hospitals in the Netherlands (data derived from the PROCORE study).
Article Synopsis
- Cancer survivors often face lasting fatigue that negatively impacts their quality of life, and it's unclear how chemotherapy, specifically doxorubicin, contributes to this fatigue.* -
- In a mouse study, doxorubicin treatment was found to reduce physical activity over five weeks without significantly affecting the central circadian clock's activity, but it did alter the timing and behavior of surrounding neuronal activity.* -
- The findings indicate that doxorubicin disrupts the communication between the central circadian clock and the body's rest-activity rhythms, which may explain the fatigue experienced by cancer survivors.*
Study Objective: To investigate the feasibility and safety of the retropubic mid-urethral sling (MUS) procedure with a resorbable mesh implant made of poly-4-hydroxybutyrate (P4HB).
Design: A prospective clinical cohort study with 24 months follow-up.
Setting: A tertiary academic hospital.
Objectives: The objective of the study was to better understand the extent of the ischemic trauma and the effects of surgical repair on the vaginal microcirculation in patients with obstetric vesicovaginal fistula (VVF).
Design: In this observational study, we evaluated the vaginal microvasculature surrounding VVF using handheld vital microscopy (HVM) before, during, and 2 weeks after surgical VVF repair.
Participants: Seventeen women undergoing VVF repair were included in this study.
Background: Ninety percent of cervical cancer (CC) diagnoses and deaths occur in low and middle-income countries (LMICs). Especially in these countries, where human and material resources are limited, there is a need for real-time screening methods that enable immediate treatment decisions (i.e.
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