Publications by authors named "A M Buzaleh"
Heme enzyme dysfunction causes a group of diseases called porphyrias. Particularly, a decrease in porphobilinogen deaminase, involved in the third step of heme biosynthesis, leads to acute intermittent porphyria (AIP). Considering our previous works demonstrating the multiplicity of brain metabolisms affected by porphyrinogenic agents, this study aimed to elucidate whether they cause any alteration on the mitochondrial respiratory chain.
View Article and Find Full Text PDFThe Multidrug Resistance protein (, ) is involved in the transport of xenobiotics and antiretroviral drugs. Some variants of the gene are of clinical importance; among them, exon 12 (c.1236C>T, rs1128503), 21 (c.
View Article and Find Full Text PDFOxidative stress is a key factor contributing to the development of diabetes complications. Glutathione -transferases (GSTs) protect against products of oxidative stress by conjugating glutathione to electrophilic substrates, producing compounds that are generally less reactive and more soluble. The expression and activity of GSTs during diabetes have been extensively studied, but little is known about regulation mechanisms of Pi-class GST (GSTP).
View Article and Find Full Text PDFRole of and glutathione S-transferase gene variants in the association of porphyria cutanea tarda and human immunodeficiency virus infection.
Biomed Rep
February 2021
Article Synopsis
- In Argentina, porphyria cutanea tarda (PCT) is linked with HIV infection, but the relationship with HIV and antiretroviral therapy remains unclear.
- The study examines specific genetic variants that influence drug metabolism and their potential role in the onset of PCT among HIV-infected patients.
- Findings show that certain gene variants are more frequent in PCT patients, suggesting that genetics, along with antiretroviral therapy, may contribute to the development of PCT in those with HIV.
Effects of volatile anaesthetics on heme metabolism in a murine genetic model of Acute Intermittent Porphyria. A comparative study with other porphyrinogenic drugs.
Biochim Biophys Acta Gen Subj
June 2018
Background: Acute Intermittent Porphyria (AIP) is an inherited disease produced by a deficiency of Porphobilinogen deaminase (PBG-D). The aim of this work was to evaluate the effects of Isoflurane and Sevoflurane on heme metabolism in a mouse genetic model of AIP to further support our previous proposal for avoiding their use in porphyric patients. A comparative study was performed administering the porphyrinogenic drugs allylisopropylacetamide (AIA), barbital and ethanol, and also between sex and mutation using AIP (PBG-D activity 70% reduced) and T1 (PBG-D activity 50% diminished) mice.
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